Compositions containing nucleosides and manganese and their uses

US9186406B2 · kind B2 · utility

Assignees

• The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. · US
• THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER—NATIONAL INSTITUTES OF HEALTH · US

Inventors

• Michael J. Daly · Washington, US
• Elena K. Gaidamakova · Gaithersburg, US
• Vera Y. Matrosova · Rockville, US
• Rodney L. Levine · Rockville, US
• Nancy B. Wehr · Bethesda, US

Key dates

• Filing date: Aug 18, 2008
• Grant date: Nov 17, 2015
• Expiry date: Mar 29, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q17/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.