Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine

US9187417B2 · kind B2 · utility

Assignee

• CELGENE CORPORATION · US

Inventors

• Jasti Venkateswaralu · Hyderabad, IN
• Chinnapillai Rajendiran · Hyderabad, IN
• Nallamaddi Ravikumar Reddy · Hyderabad, IN
• Terrence Joseph Connolly · Rocky Hill, US
• Alexander L. Ruchelman · Cream Ridge, US
• Jeffrey Eckert · Hazlet, US
• Anthony Joseph Frank · Easton, US

Key dates

• Filing date: Feb 20, 2013
• Grant date: Nov 17, 2015
• Expiry date: May 18, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.