Formation of N-protected 3,6-bis-(4-aminobutyl) -2, 5-diketopiperazine through a cyclic α-N-protected active amino ester intermediate

US9187433B2 · kind B2 · utility

Assignee

• MannKind Corporation · US

Inventors

• John J. Freeman · Longmont, US
• Otto Phanstiel · Oviedo, US
• William Elliot Bay · Martinez, US
• Kelly Sullivan Kraft · Hopewell Junction, US

Key dates

• Filing date: Feb 23, 2015
• Grant date: Nov 17, 2015
• Expiry date: Feb 23, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic α-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.