Derivatives of benzothiazines, preparation thereof and application thereof as drugs
US9187438B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Mar 2, 2010 |
| Grant date | Nov 17, 2015 |
| Priority date | — |
| Expiry date | Jul 25, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The object of the present invention is benzothiazine derivatives having the capability of inhibiting 11β-HSD1 not only at an enzymatic level but also at a cell level. The compounds of the present invention are of general formula (I). Wherein notably R1 represents a hydrogen or OR1 represents an ester or an ether. R2 represents a naphthyl or a 1,2,3,4-tetrahydro-naphthalene or a biphenyl or phenyl pyridine or a substituted phenyl. R3 represents a methyl or ethyl; R4 and R′4 represent a hydrogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.