Crystalline forms of tenofovir dipivoxil fumarate

US9187508B2 · kind B2 · utility

Assignee

• Jiangsu Chiatei Tianqing Pharmaceutical Co., LTd · CN

Inventors

• Aiming Zhang · Lianyungang, CN
• Qide Li · 安丰镇, CN
• Chunguang Xia · Lianyungang, CN
• Xiquan Zhang · 安丰镇, CN

Key dates

• Filing date: Aug 1, 2011
• Grant date: Nov 17, 2015
• Expiry date: Dec 2, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C57/15
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a crystalline form of tenofovir dipivoxil fumarate, a crystalline composition and a pharmaceutical composition comprising the crystalline form, and also to a process for preparing the same and the use for prophylaxis or treatment of a disease associated with a viral infection. The crystalline form has an X-ray powder diffraction pattern using Cu-Kα radiation, expressed in terms of lattice spacing “d” comprising peaks at about 18.4714 Å, 5.0350 Å, 4.6380 Å, 4.5347 Å, 4.3838 Å, 4.2874 Å and 3.6304 Å.