Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment

US9187509B2 · kind B2 · utility

Assignee

• PLEDPHARMA AB · SE

Inventors

• Jan-Olof Karlsson · Oslo, NO
• Karl E. Reineke · Niskayuna, US
• Tino Kurz · Säter, SE
• Rolf Andersson · Vikingstad, SE
• Michael Hall · Albany, US
• Christina McLaughlin · Albany, US
• Sven Jacobsson · Stockholm, SE
• Jacques Näsström · Bromma, SE

Key dates

• Filing date: Dec 4, 2012
• Grant date: Nov 17, 2015
• Expiry date: Dec 4, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F19/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A mixed metal complex of a compound of Formula I, or a salt thereof, wherein the mixed metals comprise a Group III-XII transition metal and a Group II metal:wherein X, R1, R2, R3, and R4 are as defined herein, is produced in a one step crystallization from a solution of the Group III-XII transition metal, the Group II metal, and a compound of Formula I. Methods for treatment of a pathological condition in a patient, for example, a pathological condition caused by the presence of oxygen-derived free radicals, comprise administering the mixed metal complex to the patient.