Ciliary neurotrophic factor variants

US9187542B2 · kind B2 · utility

Assignee

• Christian-Albrechts-Universitaet zu Kiel · DE

Inventors

• Joachim Grötzinger · Altwittenbek, DE
• Stefan Rose-John · Kiel, DE
• Jürgen Scheller · Neuss, DE
• Matthias Aurich · Radevormwald, DE

Key dates

• Filing date: Jun 13, 2012
• Grant date: Nov 17, 2015
• Expiry date: Jun 13, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acid molecule selected from the group consisting of (a) a nucleic acid molecule having a nucleotide sequence shown in SEQ ID: NO 1, (b) a nucleic acid molecule which encodes a peptide having an amino acid sequence shown in SEQ ID: NO 2, (c) a nucleic acid molecule whose complementary strand hybridizes to a nucleic acid molecule according to (a) or (b) and which codes for a peptide which binds to ciliary neurotrophic factor receptor (CNTFR), the peptide binding with lower affinity than ciliary neurotrophic factor to the interleukin-6 receptor (IL-6R), (d) a nucleic acid molecule whose nucleotide sequence differs from the nucleotide sequence of a nucleic acid molecule according to (c) due to the degenerated genetic code, the codon at positions 82-84 of the nucleic acid molecule according to (a) coding for a non-positively charged amino acid, and the peptide at position 28 shown in SEQ ID: NO 2 having a non-positively charged amino acid residue.