Alphavirus and alphavirus replicon particle formulations and methods
US9187729B2 · kind B2 · utility
6Cited by
25References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Jan 24, 2011 |
| Grant date | Nov 17, 2015 |
| Priority date | — |
| Expiry date | Jan 24, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/36151
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods for preparing dried (preferably lyophilized) preparations comprising a population of alphaviruses or alphavirus replicon particles, a sugar or polyol, a surfactant and a salt and preparations made by these methods, both in the dried form but also as liquids prior to drying or after reconstituting dried preparations. These preparations may further comprise a plasticizer and/or a bulking agent. These preparations are readily reconstituted, with little or no loss in infectivity of the viruses or replicon particles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.