Method for improving acid tolerance of Propionibacterium acidipropionici
US9187773B2 · kind B2 · utility
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Key dates
| Filing date | Oct 7, 2013 |
| Grant date | Nov 17, 2015 |
| Priority date | — |
| Expiry date | Dec 13, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a simple and effective method for improving acid tolerance of P. acidipropionici by adding arginine and/or aspartic acid to the culture medium. The acid tolerance of P. acidipropionici was improved by 60% and 20% respectively through adding arginine or aspartic acid into the culture medium. Consequently, PA production was improved by 36% and 26%, respectively. The maximal PA production was obtained by adding both 20 mM arginine and 20 mM aspartic acid. This method can be applied to large scale production of PA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.