Method for predicting the presence of reproductive cells in TESTIS
US9188582B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 31, 2012 |
| Grant date | Nov 17, 2015 |
| Priority date | — |
| Expiry date | Oct 31, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/367
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Testicular germline markers and their use for predicting the presence or not of reproductive cells in testis of an infertile or hypo fertile male subject are provided. More particularly, identification of specific protein biomarkers of post-meiotic germ cells in the human seminal plasma was carried out by an integrative genomics approach. It was demonstrated that the presence of such biomarkers could be monitored in the seminal plasma of azoospermic subjects in order to select for a testis biopsy and testicular sperm extraction (TESE) only subjects for which there are high probabilities to find reproductive cells. The results indicate the analysis of seminal plasma is a non-invasive approach for predicting the presence of reproductive cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.