Microfluidic, electrochemical devices

US9192933B2 · kind B2 · utility

Assignee

• President and Fellows of Harvard College · US

Inventors

• George M. Whitesides · Newton, US
• Zhihong Nie · Cambridge, US
• Christian Albertus Nijhuis · Somerville, US
• Xin Chen · Evanston, US
• Andres W. Martinez · Cambridge, US
• Max Narovlyansky · Cambridge, US

Key dates

• Filing date: Mar 8, 2010
• Grant date: Nov 24, 2015
• Expiry date: May 24, 2032

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2300/0887
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.