Poly(beta-amino alcohols), their preparation, and uses thereof

US9193827B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Minglin Ma · Ithaca, US
• Wendy Liu · Irvine, US
• Robert S. Langer · Newton, US
• Daniel Griffith Anderson · Framingham, US

Key dates

• Filing date: Aug 26, 2011
• Grant date: Nov 24, 2015
• Expiry date: Nov 11, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/31725
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.