Methods and compositions for mesenchymal stem cell proliferation
US9193954B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Apr 2, 2012 |
| Grant date | Nov 24, 2015 |
| Priority date | — |
| Expiry date | Apr 2, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/727
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided is a method for increasing proliferation of mesenchymal stem cells. The method entails contacting the cells with 6-bromoindirubin-3′-oxime (BIO). This results in robust proliferation and “stemness” in a dose-dependent fashion, as indicated by the gene expression of two stem cell genes: Sox2 and Nanog.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.