Combined hairpin-antisense compositions and methods for modulating expression
US9193972B2 · kind B2 · utility
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41Claims
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Key dates
| Filing date | Aug 5, 2014 |
| Grant date | Nov 24, 2015 |
| Priority date | — |
| Expiry date | Aug 5, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/53
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A nucleotide construct comprising a nucleotide sequence that forms a stem and a loop, wherein the loop comprises a nucleotide sequence that modulates expression of a target, wherein the stem comprises a nucleotide sequence that modulates expression of a target, and wherein the target modulated by the nucleotide sequence in the loop and the target modulated by the nucleotide sequence in the stem may be the same or different. Vectors, methods of regulating target expression, methods of providing a cell, and methods of treating conditions comprising the nucleotide sequence are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.