Method for determining ploidy of a cell
US9193992B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | May 15, 2013 |
| Grant date | Nov 24, 2015 |
| Priority date | — |
| Expiry date | Nov 21, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
A method for determining the ploidy of a test genome is provided. In some embodiments, the method may comprises: a) obtaining a plurality of ratios for polymorphisms that are distributed throughout a test genome, wherein each of the ratios is a ratio of the measured copy number of uncut allele in a polymorphic site relative to the measured copy number of the uncut allele in the reference sample; b) taking the log of the ratios and plotting a distribution of the reference corrected log ratios of the SNP probes; and c) determining the ploidy of said the genome based on the number of peaks in that distribution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.