Method and system for introducing make-up flow in an electrospray ion source system
US9196468B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 17, 2013 |
| Grant date | Nov 24, 2015 |
| Priority date | — |
| Expiry date | May 17, 2033 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/0431
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An electrospray ion source method and system is provided for detecting emitter failure comprising a liquid chromatography column suitable for chromatographic separation of a sample. The column can have an inlet for receiving the sample; and an outlet for ejecting the sample. A make-up flow channel is provided for introducing make-up flow of liquid to the sample post-column, wherein the make-up flow normalizes the spray current. An electrospray ionization source is provided having one or more electrospray ionization emitter nozzles for receiving the make-up flow containing sample. A power supply can provide a voltage to the one or more emitter nozzles, and a measurement device can measure and monitor the spray current.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.