Controlled vesicle self-assembly in continuous two phase flow microfluidic channels

US9198645B2 · kind B2 · utility

Assignee

• The United States of America, as Represented by the Secretary of Commerce National Institute of Standards and Technology · US

Inventors

• Andreas Jahn · Tambach-Dietharz, DE
• Wyatt N. Vreeland · Washington, US
• Laurie E. Locascio · Gaithersburg, US
• Michael Gaitan · North Potomac, US

Key dates

• Filing date: Jul 21, 2004
• Grant date: Dec 1, 2015
• Expiry date: Sep 15, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B2017/00898
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for the formation of liposomes that encapsulate reagents in a continuous 2-phase flow microfluidic network with precision control of size, for example, from 100 nm to 300 nm, by manipulation of liquid flow rates are described. By creating a solvent-aqueous interfacial region in a microfluidic format that is homogenous and controllable on the length scale of a liposome, fine control of liposome size and polydispersity can be achieved.