Compositions of and methods of using ligand dimers
US9198952B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Sep 22, 2009 |
| Grant date | Dec 1, 2015 |
| Priority date | — |
| Expiry date | Jun 28, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are ligand dimers, compositions thereof, as well as methods of their use. The ligand dimers provided can comprise at least one ligand to a Her receptor and can be used to force dimerization of specific receptor pairs. The forced dimerization of specific receptor pairs can be used to control (e.g., promote or inhibit) signaling, and, therefore, the ligand dimers provided can also be used in various forms of treatment in which such signaling control is beneficial to a subject. It follows that methods for controlling signaling are provided as are various methods of treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.