Biaryl-propionic acid derivatives and their use as pharmaceuticals

US9199947B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Sven Ruf · Mainz, DE
• Thorsten Sadowski · Frankfurt am Main, DE
• Klaus Wirth · Frankfurt am Main, DE
• Herman Schreuder · Frankfurt am Main, DE
• Christian Buning · Frankfurt am Main, DE
• Christopher Kallus · Frankfurt am Main, DE
• Hartmut Strobel · Liederbach, DE
• Hermut Wehlan · Frankfurt am Main, DE

Key dates

• Filing date: Mar 27, 2014
• Grant date: Dec 1, 2015
• Expiry date: Apr 15, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the formula I,wherein X, R, R1, R2, D, E1, E2, E3, E4, G1, G2, G3 and G4 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.