Amorphous form of cabazitaxel and process for its preparation

US9199953B2 · kind B2 · utility

Assignee

• Fresenius Kabi Oncology Ltd. · IN

Inventors

• Saswata Lahiri · Sindhar, IN
• Bhuwan Bhaskar Mishra · Manesar, IN
• Vijay Ojha · Manesar, IN
• Nilendu Panda · Barwala, IN
• Sonu Prasad SHUKLA · Sindhar, IN

Key dates

• Filing date: Oct 30, 2012
• Grant date: Dec 1, 2015
• Expiry date: Mar 2, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D305/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An amorphous form of cabazitaxel is disclosed. It is preferably characterized by an X-ray powder diffraction (XRD) pattern as depicted in FIG. 1. It is prepared by (a) preparing a solution of cabazitaxel in a suitable solvent and mixture thereof; and (b) recovering the amorphous forms of cabazitaxel from the solution by removal of the solvent.