Acrylamide compounds and use thereof for inhibiting apoptosis

US9199978B2 · kind B2 · utility

Assignee

• CHINESE PLA GENERAL HOSPITAL · CN

Inventors

• Kunluu He · Beijing, CN
• Song Li · Beijing, CN
• Wu Zhong · Beijing, CN
• Juan Liu · 安丰镇, CN
• Lili Wang · Beijing, CN
• Xin Li · Shanghai, CN
• Guoliang Hu · Nanchang, CN
• Jie Wang · Lake Bluff, US
• Long Long · Beijing, CN
• Junhai Xiao · Beijing, CN
• Zhibing Zheng · Beijing, CN
• Wei Li · Lexington, US
• Ruijun Li · Parramatta, AU
• Chunlei Liu · Shanghai, CN
• Jie Tang · Singapore, SG

Key dates

• Filing date: May 14, 2010
• Grant date: Dec 1, 2015
• Expiry date: Mar 13, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.