Enzyme-degradable polymer and application thereof
US9200033B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 24, 2011 |
| Grant date | Dec 1, 2015 |
| Priority date | — |
| Expiry date | Aug 19, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer. The present invention also provides hydrogels, nano-particles, fluorescent dye-labeled enzyme substrates and kits (packages) for detection or activity-analysis of biological enzymes based on the enzyme-degradable polymer. The formula of the enzyme-degradable polymer is P1-(aa)N-(AA)n-X X=[formula 1] wherein, (aa)N is a non-enzyme substrate domain, the N aa may be different (no correlation), and N is a non-negative integer; (AA)n is an enzyme substrate domain, the n AA may be different, and n is a non-negative integer; P1 is a protecting group of α-amino or functional group; P2 is a protecting group of α-amino; P3 is —NH2, a small molecule compound or a fragment of a polymer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.