Cyclosporine analogue molecules modified at amino acid 1 and 3
US9200038B2 · kind B2 · utility
5Cited by
71References
28Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 14, 2011 |
| Grant date | Dec 1, 2015 |
| Priority date | — |
| Expiry date | Dec 14, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Analogs of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.