Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i

US9200061B2 · kind B2 · utility

Assignee

• MORPHOSYS AG · DE

Inventors

• Michael Tesar · Heidelberg, DE
• Ute Jaeger · Munich, DE

Key dates

• Filing date: Nov 22, 2011
• Grant date: Dec 1, 2015
• Expiry date: Nov 22, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods for using recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods take advantage of newly discovered antibodies and surprising properties of such antibodies, such as the ability to bind CD38 of minipig origin and the ability to induce, by cross-linking, specific killing of cells that express CD38. These antibodies as well as the methods for using those antibodies can be used to treat, for example, hematological malignancies such as multiple myeloma.