Co-culture device assembly

US9200246B2 · kind B2 · utility

Assignee

• ACEA Biosciences, Inc. · US

Inventors

• Donald Thomas · Vista, US
• Wei Li · Markham, CA
• Ning Ke · San Diego, US
• Nan Li · Beijing, CN
• Adrian Papas · San Diego, US
• Manfred Watzele · Weilheim, DE
• Alexander Seiler · Habach, DE
• Tianxing Wang · Hangzhou City, CN
• Yama A. Abassi · San Diego, US
• Xiaobo Wang · San Diego, US

Key dates

• Filing date: Dec 1, 2011
• Grant date: Dec 1, 2015
• Expiry date: Dec 1, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/48735
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An insert device and co-culture device assembly incorporating the insert device, which includes an insert chamber with two fluid impermeable side walls that extend from a microporous bottom to an open top to form an inner cavity. The first side wall is shaped to form a convex arc that follows between about half of a circumference of the well and less than an entire circumference of the well. The second side wall joins ends of the first side wall and protrudes inward towards a center of the convex arc. A flange extends outward from or beneath the top and is notched to form a gap adjacent to the second side wall, which forms an access port allowing access to the lower chamber with a micropipette tip when the insert device is inserted into a well of a single or multi-well plate.