Marine streptomyces, pyranosesquiterpene compound, as well as preparation method and applications thereof

US9200301B2 · kind B2 · utility

Assignee

• SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Lijuan Long · 流花街道, CN
• Xinpeng Tian · 流花街道, CN
• Jie Li · Shanghai, CN
• Xiongming Luo · 流花街道, CN
• Zhenxiong Qi · 流花街道, CN
• Tuan Yin · 流花街道, CN
• Hao Yin · Chengdu, CN
• Jian Yang · State College, US

Key dates

• Filing date: Aug 16, 2012
• Grant date: Dec 1, 2015
• Expiry date: Dec 8, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/465
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention discloses marine Streptomyces sp., a Pyranosesquiterpene compound, as well as a preparation method and uses thereof. Streptomyces sp. SCSIO 01689 was collected in China Center for Type Culture Collection (CCTCC) (Address: Wuhan University, Wuhan City, China) with the collection number of CCTCC NO: M 2011257 on Jul. 18, 2011. The Streptomyces sp. SCSIO 01689 can produce the Pyranosesquiterpene compound with better anti-Escherichia coli activity and anti-Artemia activity, as well as Cyclo(D)-Pro-(D)-Ile, Cyclo(D)-Pro-(D)-Leu and Cyclo(D)-trans-4-OH-Pro-(D)-Phe with better anti-Vibrio anguillarum activity and anti-Artemia activity, thereby providing a new way for preparing the Cyclo(D)-Pro-(D)-Ile, the Cyclo(D)-Pro-(D)-Leu and the Cyclo(D)-trans-4-OH-Pro-(D)-Phe. The Pyranosesquiterpene compound can be used for preparing anti-Escherichia coli medicaments and anti-Artemia medicaments, as well as preparing condiments as a condiment precursor compound.