Process for producing a solid dispersion of an active ingredient

US9205027B2 · kind B2 · utility

Assignee

• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Thomas Kessler · Schifferstadt, DE
• Jorg Breitenbach · Mannheim, DE
• Christoph Schmidt · Kriftel, DE
• Matthias Degenhardt · Ludwigshafen, DE
• Jörg Rosenberg · Ellerstadt, DE
• Harald Krull · Ludwigshafen, DE

Key dates

• Filing date: Dec 2, 2013
• Grant date: Dec 8, 2015
• Expiry date: Mar 20, 2034

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29K2105/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element (FIG. 2).