Solubilized ibuprofen

US9205054B2 · kind B2 · utility

Assignee

• Losan Pharma GmbH · DE

Inventors

• Peter Gruber · Bottmingen, CH
• Wolfgang Mohr · Freiburg (Elbe), DE

Key dates

• Filing date: Mar 22, 2006
• Grant date: Dec 8, 2015
• Expiry date: Nov 22, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for producing a solubilized ibuprofen, preferably in the form of a granulate, the process comprising the steps of: providing a mixture comprising solid ibuprofen and a first base selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium glycinate, potassium glycinate and tribasic sodium and potassium phosphates and mixtures thereof, and reacting the ibuprofen and the first base in essentially dry state. The obtainable granulate and the pharmaceutical compositions and dosage forms that may be produced therefrom are distinguished by their high solubility and rapid disintegration and dissolution in aqueous media, by their good flow properties and compressibility, by rapidly achieving onset of analgesic effect.