Antibodies and other molecules that bind B7-H1 and PD-1
US9205148B2 · kind B2 · utility
66Cited by
20References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 19, 2012 |
| Grant date | Dec 8, 2015 |
| Priority date | — |
| Expiry date | Aug 14, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to B7-H1 or PD-1. In some embodiments such molecules are additionally capable of modulating the ability of B7-H1 or B7-DC to bind to PD-1 or are capable of affecting the signaling activity of the B7-H1 or PD-1. The invention additionally concerns the uses of such molecules in the diagnosis and treatment of cancer and other diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.