Process for preparing high purity ursodeoxycholic acid
US9206220B2 · kind B2 · utility
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Key dates
| Filing date | Jul 30, 2013 |
| Grant date | Dec 8, 2015 |
| Priority date | — |
| Expiry date | Jul 30, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J75/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention describes a process for the synthesis of ursodeoxycholic acid wherein the purification of the crude ursodeoxycholic acid (containing approximately 13-15% of chenodeoxycholic acid impurity) takes place first passing through a salification with imidazole and a subsequent purification via “methyl ester”, which allows a finished product with an extremely low content of known “cheno and “litho” impurities to be obtained. The present invention also describes the recovery steps of cholic acid and 3α-hydroxy-7-ketocholanic acid from the mother liquors of process intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.