Utilization of pharmacological chaperones to improve manufacturing and purification of biologics
US9206457B2 · kind B2 · utility
48Cited by
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7Claims
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Assignee
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Key dates
| Filing date | Nov 22, 2010 |
| Grant date | Dec 8, 2015 |
| Priority date | — |
| Expiry date | Nov 22, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y302/01054
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of the protein out of the cell's endoplasmic reticulum, and increase secretion of the protein by the cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.