Patent · US Active

Compositions and methods for topical application and transdermal delivery of botulinum toxins

US9211248B2 · kind B2 · utility

12Cited by
138References
76Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMar 18, 2013
Grant dateDec 15, 2015
Priority date—
Expiry dateMar 18, 2033

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2319/10
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain polypeptide or nonpeptidyl polymer having attached positively charged branching or “efficiency” groups. The invention also relates to methods for reducing muscle paralysis and other conditions that may be treated with a botulinum toxin, particularly paralysis of subcutaneous, and most particularly, facial, muscles, by topically applying an effective amount of the botulinum toxin and carrier, in conjunction, to the subject's skin or epithelium. Kits for administration are also described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.