Methods and compositions for treating post-operative pain comprising clonidine

US9211285B2 · kind B2 · utility

Assignee

• Warsaw Orthopedic, Inc.

Inventors

• William F. McKay · Memphis, US
• Amira Wohabrebbi · Memphis, US
• Vanja Margareta King · Memphis, US
• Phillip Edward McDonald · Plymouth, US
• Christopher M. Hobot · Brooklyn Park, US
• Troy Carter · Abilene, US

Key dates

• Filing date: Dec 5, 2013
• Grant date: Dec 15, 2015
• Expiry date: Dec 5, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/604
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.