Methods and compound to inhibit Ca2+ permeable cation conductance

US9211313B2 · kind B2 · utility

Assignees

• The Research Foundation of the State University of New York · US
• Beth Israel Deaconess Medical Center, Inc. · US

Inventors

• Frederick Sachs · Buffalo, US
• Philip Gottlieb · Buffalo, US
• Thomas Suchyna · Amherst, US
• Seth L. Alper · Brookline, US
• David H. Vandorpe · Watertown, US
• Chang Xu · Tucson, US

Key dates

• Filing date: Jan 17, 2012
• Grant date: Dec 15, 2015
• Expiry date: May 30, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.