Deletion mutants of flagellin and methods of use

US9211320B2 · kind B2 · utility

Assignee

• VaxInnate Corporation · US

Inventors

• Langzhou Song · Cranbury, US
• Lynda G. Tussey · Princeton, US
• Alan R. Shaw · Cranbury, US
• Robert S. Becker · Henryville, US
• Yi Zhang · Edison, US
• Scott Umlauf · Cranbury, US
• Ge Liu · Tianjin, CN

Key dates

• Filing date: Dec 17, 2014
• Grant date: Dec 15, 2015
• Expiry date: Dec 17, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions that include at least a portion of a flagellin and an antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to infection.