Dressing compositions and methods

US9211358B2 · kind B2 · utility

Assignee

• Rutgers, the State University of New Jersey · US

Inventors

• Patrick J. Sinko · Lebanon, US
• Stanley Stein · East Brunswick Township, US
• Anupa R. Menjoge · Highland Park, US
• Simi Gunaseelan · Highland Park, US
• Siva Naga Sree Priay Anumolu · Morristown, US
• Raghavandra Navath · Detroit, US

Key dates

• Filing date: Apr 23, 2008
• Grant date: Dec 15, 2015
• Expiry date: Apr 13, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/602
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.