Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US9211410B2 · kind B2 · utility
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246References
24Claims
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Key dates
| Filing date | Jul 21, 2014 |
| Grant date | Dec 15, 2015 |
| Priority date | — |
| Expiry date | Jul 21, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/37205
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation with progressively longer delays (off periods) from an initial stimulation. In particular, described herein are supra-threshold pulses of electrical stimulation sufficient to result in a long-lasting (e.g., >48 hours) inhibition of pro-inflammatory cytokines and/or effects of chronic inflammation; the delay between initial doses (which may be single-pulse doses) may be extended for subsequent doses, potentially dramatically enhancing battery and device longevity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.