Polyamine transport inhibitors as novel therapeutics
US9212131B2 · kind B2 · utility
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Key dates
| Filing date | Jun 21, 2010 |
| Grant date | Dec 15, 2015 |
| Priority date | — |
| Expiry date | Sep 9, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel polyamine transport inhibitors have been synthesized and demonstrated to block the uptake of native polyamines into human cancer cells. A combination therapy of the transport inhibitor and DFMO (a drug which blocks polyamine biosynthesis) provided synergistic activity against a metastatic human colon cancer cell line. The strategy uses polyamine depletion and polyamine metabolism to generate reactive oxygen species within cells as a novel way to treat cancers. This approach may be implemented for widespread use in the treatment of diseases which rely upon polyamine transport activity for proliferation.
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