Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof
US9212196B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 16, 2012 |
| Grant date | Dec 15, 2015 |
| Priority date | — |
| Expiry date | May 16, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4816
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to hypophosphorous acid derivatives of formula (I) wherein —X is H or OH, —R represents one or several radicals R1-R5, identical or different, two of R1-R5 optionally occupying the same position on the phenyl group, one to four of R1-R5 being H and the others being selected in the group comprising -0-(CH2)n—COOH; —S—(CH2)n—COOH; —NH—(CH2)n—COOH; -0-(CH,R′)—COOH; —O—(CH2)n—OH; OR′, —R′ being a C1-C3 alkyl radical; —OH; —COOH; halogen, particularly —F, —CI, —Br, —I, —CF3; —OCF3; —N02; —CH═CH—COOH; —(CH2)n—COOH; O—(CH2)n—P03H2; O—(CF2)n—P03H2; O—(CH2)n—S03H; O—(CH2)n—CONHOH; O—(CH2)n-tetrazol; O—(CH2)n-hydroxyisoxazol—n=1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.