Nucleic acid binding compounds and methods of use
US9212205B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 28, 2008 |
| Grant date | Dec 15, 2015 |
| Priority date | — |
| Expiry date | Aug 28, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/047
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also disclosed. The present invention also relates to monomer compounds capable of forming homo- or hetero-dimer compounds, as well as oligomers formed via linkage of one or more dimers. Also disclosed are methods of inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-I RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. The dimer compounds can also be used for selectively detecting presence of the target RNA molecule in a sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.