Synthesis of sialic acid in plants
US9212372B2 · kind B2 · utility
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3Claims
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Key dates
| Filing date | Feb 9, 2007 |
| Grant date | Dec 15, 2015 |
| Priority date | — |
| Expiry date | Nov 7, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y401/03003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
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