Antofine and cryptopleurine derivatives as anticancer agents

US9216977B2 · kind B2 · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• National Taiwan University · TW

Inventors

• Kuo-Hsiung Lee · Chapel Hill, US
• Xiaoming Yang · San Diego, US
• Qian Shi · Chapel Hill, US
• Kenneth F. Bastow · Chapel Hill, US
• Che-Ming Teng · Taipei, TW
• Tse-Ming Hong · Taipei, TW
• Pan-Chyr Yang · Taipei, TW
• Shuenn-Chen Yang · Taipei, TW

Key dates

• Filing date: Sep 22, 2010
• Grant date: Dec 22, 2015
• Expiry date: Oct 1, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.