Patent · US Active

Non human animal model for ulcerative colitis and its main complications

US9217156B2 · kind B2 · utility

0Cited by

0References

6Claims

0Family size

Assignee

Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

Eric OGIER-DENIS · Paris, FR
Xavier TRETON · Paris, FR
Fanny Daniel · Paris, FR
Cecile Guichard · Paris, FR
Eric Pedruzzi · Paris, FR
Yoram BOUHNIK · Paris, FR
Yann Harnoy · Paris, FR

Key dates

Filing date	Apr 13, 2012
Grant date	Dec 22, 2015
Priority date	—
Expiry date	Jul 25, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2015/8527
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a non human model animal for ulcerative colitis and its main complications such as primary sclerosing cholangitis and colorectal cancer. More particularly, the present invention relates to a transgenic non human animal model for ulcerative colitis and its main complications such as primary sclerosing cholangitis, and colorectal cancer comprising a targeted disruption in the IL10 and NOX1 genes so that IL10 and NOX1 are not expressed in said animal.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.