System and method for detecting amyloid proteins
US9220403B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 12, 2011 |
| Grant date | Dec 29, 2015 |
| Priority date | — |
| Expiry date | Jun 28, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2562/0242
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.