Methods and compositions for CNS delivery of iduronate-2-sulfatase
US9220677B2 · kind B2 · utility
13Cited by
12References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 23, 2013 |
| Grant date | Dec 29, 2015 |
| Priority date | — |
| Expiry date | Sep 20, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y310/01001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.