Polyenolic zinc-binding agents (pezbins) actively promote inactivation of cancer stem cells and potentiate cytotoxic anti-tumor drug substances

US9220695B2 · kind B2 · utility

Assignee

• The Research Foundation for The State University of New York · US

Inventors

• Lorne M. Golub · Smithtown, US
• Francis Johnson · Setauket, US
• Galina I. Botchkina · Stony Brook, US
• Iwao Ojima · Port Jefferson, US

Key dates

• Filing date: Jun 28, 2013
• Grant date: Dec 29, 2015
• Expiry date: Jun 28, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure:or a pharmaceutically acceptable salt thereof.