Patent · US Active

4-substituted-(3-substituted-1H-pyrazole-5-amino)-pyrimidine derivatives having activity of inhibiting protein kinase and use thereof

US9221798B2 · kind B2 · utility

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28Claims

0Family size

Assignee

Zhejiang Hisun Pharmaceutical Co., Ltd. · CN

Inventors

Yili Ding · San Diego, US
Xuan Yang · Longbeilingcun, CN
Qingyan Yan · Shanghai, CN
Hua Bai · Lake Jackson, US
Lifeng Cai · Zhejiang, CN
Kenneth Thomas Smith · Shanghai, CN
Jian Chai · Zhejiang, CN

Key dates

Filing date	Sep 5, 2011
Grant date	Dec 29, 2015
Priority date	—
Expiry date	Sep 5, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided are derivatives substituted by urea associated with 4-substituted-(3-substituted-1H-pyrazole-5-amino)-pyrimidine-2-amino of formula (I), wherein these compounds may selectively regulate or inhibit an information transmission process controlled by natural or variant tyrosine kinase. Also provided are preparation methods and uses of the compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.