Macrocycles as factor XIa inhibitors
US9221818B2 · kind B2 · utility
12Cited by
0References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 6, 2012 |
| Grant date | Dec 29, 2015 |
| Priority date | — |
| Expiry date | Aug 6, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.