Heterocyclic amide derivatives as P2X7 receptor antagonists

US9221832B2 · kind B2 · utility

Assignee

• Actelion Pharmaceuticals Ltd. · CH

Inventors

• Kurt Hilpert · Therwil, CH
• Francis Hubler
• Thierry Kimmerlin · Allschwil, CH
• Dorte Renneberg · Allschwil, CH
• Simon Stamm · Allschwil, CH
• Mark Murphy · Allschwil, CH

Key dates

• Filing date: Jul 20, 2012
• Grant date: Dec 29, 2015
• Expiry date: Jul 20, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/048
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.