Muteins of human lipocalin 2 with affinity for CTLA-4

US9221885B2 · kind B2 · utility

Assignee

• Pieris AG · DE

Inventors

• Gabriele Matschiner · Munich, DE
• Andreas Hohlbaum · Paunzhausen, DE
• Arne Skerra · Freising, DE

Key dates

• Filing date: Dec 2, 2011
• Grant date: Dec 29, 2015
• Expiry date: Aug 26, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/70521
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to novel, specific-binding therapeutic and/or diagnostic proteins directed against Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) also known as CD152, which proteins preferably are muteins of a lipocalin protein, more preferably of lipocalin 2 (Lcn2 or NGAL). The invention also relates to nucleic acid molecules encoding such proteins and to methods for generation and use of such proteins and nucleic acid molecules. Accordingly, the invention also is directed to pharmaceutical and/or diagnostic compositions comprising such lipocalin proteins, including uses of these proteins.